Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors.
Kord M KoberAdam OlshenYvettte P ConleyMark SchumacherKimberly ToppBetty SmootMelissa MazorMargaret ChesneyMarilyn HammerSteven M PaulJon D LevineChristine MiaskowskiPublished in: Molecular pain (2018)
This study is the first to provide molecular evidence that a number of mitochondrial dysfunction mechanisms identified in preclinical models of various types of neuropathic pain including chemotherapy-induced peripheral neuropathy are found in breast cancer survivors with persistent PIPN and suggest genes for validation and as potential therapeutic targets.