YAP-galectin-3 signaling mediates endothelial dysfunction in angiotensin II-induced hypertension in mice.

Zheng-Da PangXia SunRu-Yue BaiMeng-Zhuan HanYong-Jian ZhangWei WuYu ZhangBao-Chang LaiYi ZhangYan WangXiao-Jun DuXiu-Ling Deng

Published in: Cellular and molecular life sciences : CMLS (2023)

Our results demonstrate for the first time that Ang II upregulates Gal-3 expression via increment in YAP nuclear localization in vascular endothelium, and that Gal-3 mediates endothelial dysfunction contributing to the development of hypertension.

Keyphrases

angiotensin ii
blood pressure
angiotensin converting enzyme
vascular smooth muscle cells
poor prognosis
high glucose
nitric oxide
diabetic rats
drug induced
binding protein
metabolic syndrome
skeletal muscle