JPT2 in subclinical hypothyroidism-related miscarriage as a transcription co-factor: involvement of LEPR/STAT3 activation.

Y-Y ZhouS-Y ZhaoF-J HuangL-J ZhangY-L LiuJ WangXiaojun Ma

Published in: Journal of endocrinological investigation (2024)

Our results revealed that JPT2, which was downregulated in the aborted placenta from SCH rats, promoted proliferation, migration, invasion, spheroid formation, and attachment of trophoblast cells via regulating LEPR/STAT3 axis as a transcription co-factor. It is indicated that low expression of JPT2 may contribute to the abortion in individuals with SCH.

Keyphrases

induced apoptosis
cell proliferation
transcription factor
poor prognosis
signaling pathway
cell cycle arrest
cell migration
single cell
endoplasmic reticulum stress
binding protein
oxidative stress
replacement therapy
long non coding rna
drug induced