Deep-learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of isolated photoreceptor degeneration in geographic atrophy patients receiving C3 inhibition treatment.
Dun Jack FuSophie GlintonVeronika LipkovaLivia FaesBart LiefersGongyu ZhangNikolas PontikosAlex McKeownLukas ScheiblerPraveen J PatelPearse A KeaneKonstantinos BalaskasPublished in: The British journal of ophthalmology (2023)
Eyes treated PM showed significantly slower mean change of cRORA progression at 12 and 18 months (0.151 and 0.277 mm, p=0.0039; 0.251 and 0.396 mm, p=0.039, respectively) and RPE loss (0.147 and 0.287 mm, p=0.0008; 0.242 and 0.410 mm, p=0.00809). PEOM showed significantly slower mean change of RPE loss compared with sham at 12 months (p=0.0313). Intact macular areas were preserved in PM compared with sham at 12 and 18 months (p=0.0095 and p=0.044). PRD in isolation and intact macula areas was predictive of reduced cRORA growth at 12 months (coefficient 0.0195, p=0.01 and 0.00752, p=0.02, respectively) CONCLUSION: The OCT evidence suggests that pegcetacoplan slows progression of cRORA overall and RPE loss specifically while protecting the remaining photoreceptors and slowing the progression of healthy retina to iRORA.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- deep learning
- particulate matter
- air pollution
- machine learning
- computed tomography
- heavy metals
- high throughput
- cross sectional
- risk assessment
- magnetic resonance
- clinical trial
- single cell
- convolutional neural network
- replacement therapy
- diffusion weighted imaging