The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta-analysis.

Arnold Yu Lok WongG Michael MallowSabina M Pinto Alexander L HornungSamuel S RudisillKhaled AboushaalaPeter M UdbyHoward S AnDino Samartzis

Published in: JOR spine (2023)

Although oral antibiotics were statistically superior to placebo in reducing LBP-related disability in patients with CLBP and concomitant MC1, its clinical significance remains uncertain. Future large-scale high-quality RCTs are warranted to validate the effectiveness of antibiotics in individuals with CLBP.

Keyphrases

randomized controlled trial
multiple sclerosis
systematic review
clinical trial
double blind
study protocol
replacement therapy
smoking cessation
drug induced