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Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas.

Jordi RodonAnna Z MykytynGuillermo CanteroIrina C AlbulescuBerend-Jan BoschAlexander BrixJean-Christophe AudonnetAlbert BensaidJúlia Vergara-AlertBart L HaagmansJoaquim Segalés
Published in: One health outlook (2022)
Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.
Keyphrases
  • respiratory syndrome coronavirus
  • sars cov
  • coronavirus disease
  • global health
  • public health
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