Aberrant methylation-mediated downregulation of lncRNA CCND2 AS1 promotes cell proliferation in cervical cancer.

Chengcheng ZhaoJian LiuHuazhang WuJiaojiao HuJianquan ChenJie ChenFengchang Qiao

Published in: Journal of biological research (Thessalonike, Greece) (2020)

CCND2 AS1 expression is downregulated in cervical cancer, potentially through increased CCND2 AS1 promoter methylation, and the upregulation of CCND2 AS1 expression inhibited tumor growth. These data suggest that CCND2 AS1 could be a diagnostic marker and potential therapeutic target for cervical cancer.

Keyphrases

cell proliferation
poor prognosis
dna methylation
long non coding rna
genome wide
gene expression
signaling pathway
binding protein
transcription factor
electronic health record
risk assessment
deep learning