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Bu4NI-catalyzed, oxidative C(sp2)-C(sp3) cross dehydrogenative coupling for the regioselective direct C-3 benzylation of 2H-indazoles.

Lalit YadavSandeep Chaudhary
Published in: Organic & biomolecular chemistry (2022)
A Bu4NI-catalyzed, DTBP-promoted, regioselective C(sp2)-C(sp3) cross dehydrogenative coupling (CDC) protocol for the direct C-3 benzylation of 2H-indazoles is reported. The metal-free protocol is operationally simple and proceeds mechanistically via the generation of stable benzylic free-radicals followed by regioselective addition at the C-3 position of 2H-indazoles which afforded C-3 benzylated 2H-indazoles up to 87% yields. The methodology showed a varied array of functional group tolerance and wide substrate compatibility. The gram-scale synthesis further highlights the importance and versatile nature of this methodology.
Keyphrases
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