Influence of genetics and the pre-vaccination blood transcriptome on the variability of antibody levels after vaccination against Mycoplasma hyopneumoniae in pigs.

Fany Blanc Tatiana Maroilley Manuel RevillaGaëtan LemonnierJean-Jacques LeplatYvon BillonLaure RavonOlivier BouchezJean-Pierre Bidanel Bertrand Bed'hom Marie-Hélène Pinard-van der Laan Jordi Estellé Claire Rogel-Gaillard

Published in: Genetics, selection, evolution : GSE (2021)

We confirmed the influence of the host genetics on vaccine effectiveness to M. hyo and provided evidence that the pre-vaccination blood transcriptome co-varies with the Ab response. Our results highlight that both genetic markers and blood biomarkers could be used as potential predictors of vaccine response levels and more studies are required to assess whether they can be exploited in breeding programs.

Keyphrases

genome wide
rna seq
gene expression
single cell
randomized controlled trial
systematic review
public health
risk assessment
copy number
human health