Mechanical injury and IL-1β regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes.

Chunli WangQingjia ChiYongqiang ShaKang XuChunming XuCheng ChenWei HuangPeixing ChenPeter ChenLi YangK L Paul Sung

Published in: Biotechnology letters (2020)

SCs can either inhibit or increase LOX production in the presence of IL-1β, while promoting the accumulation of MMP in injured ACLfs. These results may provide crucial insights into the mechanisms underlying ACL poor healing capacity after injury.

Keyphrases

poor prognosis
cell migration
transcription factor
extracellular matrix
binding protein