Hypoxia and anaerobic metabolism relate with immunologically cold breast cancer and poor prognosis.
Alexandra GiatromanolakiAnastasia G GkegkaStamatia PouliliouEirini BiziotaStylianos KakolyrisMichael I KoukourakisPublished in: Breast cancer research and treatment (2022)
Overexpression of LDH5, an event directly related to HIF1α overexpression, characterizes a third of breast tumors, which is more frequent in TNBC. Both HIF1α and LDH5 define cold breast cancer microenvironment and poor prognosis. A rational is provided to study further whether metabolic manipulations targeting HIF and LDH5 may enhance the antitumor immune response in breast cancer.