Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme: a population-based cohort study.
Clare A AitkenHeleen M E van AgtAlbert G SiebersFolkert J van KemenadeHubert G M NiestersWillem J G MelchersJudith E M VedderRob SchuurmanAdriaan J C van den BruleHans C van der LindenJohn W J HinrichsAnco MolijnKlaas J HoogduinBettien M van HemelInge M C M de KokPublished in: BMC medicine (2019)
This is the first time that comprehensive results of nationwide implementation of hrHPV-based screening have been reported using high-quality data with a long follow-up. We have shown that both benefits and potential harms are higher in one screening round of a well-implemented hrHPV-based screening programme than in an established cytology-based programme. Lower participation in the new hrHPV programme may be due to factors such as invitation policy changes and the phased roll-out of the new programme. Our findings add further to evidence from trials and modelling studies on the effectiveness of hrHPV-based screening.