Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model.

Tien-Phat V HuynhChao WangAinsley C TranG Travis TaborThomas E MahanCaroline M FrancisMary Beth FinnRebecca SpellmanMelissa ManisRudolph E TanziJason D UlrichDavid M Holtzman

Published in: Molecular neurodegeneration (2019)

Altogether, these new knock-in strains offer a novel and dynamic tool to study the role of APOE in AD pathogenesis in a spatially and temporally controlled manner.

Keyphrases

cognitive decline
high fat diet
escherichia coli
type diabetes
adipose tissue