Protective Effect of Grape Seed Procyanidins against H2 O2 -Induced Oxidative Stress in PC-12 Neuroblastoma Cells: Structure-Activity Relationships.

Lanxin LuoRuifang BaiYuqing ZhaoJing LiZongmin WeiFang Wang Baoshan Sun

Published in: Journal of food science (2018)

This work evaluated the protective effect of procyanidins against oxidative stress in PC-12 neuroblastoma cells and established their activity-structure relationships, which provides useful cellular evidence for the further investigating the structure-optimizing and function-exploiting of procyanidins.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
hydrogen peroxide
dna damage
nitric oxide
diabetic rats
heat shock protein