Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus.

Felice RivelleseSotiria Manou-StathopoulouDaniele MauroKatriona GoldmannDebasish PyneRavindra RajakariarPatrick GordonPeter SchaferMichele BombardieriCostantino PitzalisMyles J Lewis

Published in: Lupus science & medicine (2021)

These results demonstrate the relevance of Ikaros and Aiolos as therapeutic targets in SLE due to their ability to modulate B cell activation and differentiation downstream of TLR7.

Keyphrases

transcription factor
systemic lupus erythematosus
inflammatory response
toll like receptor
disease activity
cancer therapy
dna binding