Increased cell-free fetal DNA release after apoptosis and sterile inflammation in human trophoblast cells.
Nazanin Yeganeh KazemiBohdana FedyshynIsabel YelsaYaroslav FedyshynRodrigo RuanoSvetomir N MarkovicRana ChakrabortyElizabeth Ann L EnningaPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
These data show that apoptosis and sterile inflammation induced by DOX and HMGB1, respectively, cause an increase in cffDNA concentrations in both first-trimester and term trophoblasts. Understanding physiologic release of cffDNA during healthy and complicated pregnancy can identify new targets for the diagnosis and treatment of gestational complications.
Keyphrases
- cell free
- cell cycle arrest
- oxidative stress
- induced apoptosis
- cell death
- circulating tumor
- endoplasmic reticulum stress
- pi k akt
- endothelial cells
- pregnancy outcomes
- pregnant women
- weight gain
- preterm infants
- signaling pathway
- induced pluripotent stem cells
- preterm birth
- risk factors
- birth weight
- electronic health record
- gestational age
- cell proliferation
- machine learning
- body mass index
- pluripotent stem cells
- weight loss