Trait profiles in difficult-to-treat asthma: clinical impact and response to systematic assessment.

Tiffany LinPham JonathanEve DentonJoy Wei-Yan LeeFiona Hore-LacyAsger SverrildStephanie StojanovicTunn Ren TayKavitha Garuna MurtheeNaghmeh RadhakrishnaMonique DolsJanet BondarenkoJanine MahoneyRobyn Elizabeth O'HehirEli DabscheckMark Hew

Published in: Allergy (2023)

Distinct trait profiles in difficult-to-treat asthma are associated with different clinical outcomes and treatment responsiveness to systematic assessment. These findings yield clinical and mechanistic insights into difficult-to-treat asthma, offer a conceptual framework to address disease heterogeneity, and highlight areas responsive to targeted intervention.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
randomized controlled trial
genome wide
single cell
gene expression
dna methylation
smoking cessation