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Spherical nucleic acid reporter-based cascade CRISPR/Cas12a amplifier for stable and sensitive biosensing of circulating tumor DNA.

Min ZhouYao YinYuyan ShiZhaoxin HuangYu ShiMei ChenGuoliang KeXiao-Bing Zhang
Published in: Chemical communications (Cambridge, England) (2022)
Stable and sensitive ctDNA biosensing in complex biological fluid is highly important but still remains a challenge. Herein, we develop a spherical nucleic acid reporter-based cascade CRISPR/Cas12a amplifier with improved stability and sensitivity (5 orders of magnitude).
Keyphrases
  • nucleic acid
  • crispr cas
  • circulating tumor
  • genome editing
  • cell free
  • circulating tumor cells
  • label free