Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression.
Yi-Tian YangYuxiang SongXuan ZhangWeixing ZhaoTao MaYi LiuPenglei MaYifan ZhaoHong ZhangPublished in: Psychopharmacology (2020)
Ketamine can rapidly relieve CPSP-induced depression in rats, which may be related to the reduction of proinflammatory cytokines, regulating oxidative stress and increasing BDNF in the hippocampus.
Keyphrases
- anti inflammatory
- pain management
- oxidative stress
- diabetic rats
- depressive symptoms
- poor prognosis
- chronic pain
- sleep quality
- drug induced
- stress induced
- high glucose
- dna damage
- ischemia reperfusion injury
- spinal cord injury
- cognitive impairment
- signaling pathway
- physical activity
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage