A Meta-Analysis of the Antidepressant Responses in Pivotal Trials on Esketamine Nasal Spray and Atypical Antipsychotics.

Lien WangXiaowei ChenXiaojing GuHeidi De SmedtVanina PopovaDong-Jing FuCarla M CanusoWayne C DrevetsGuang Chen

Published in: Neuropsychiatric disease and treatment (2023)

The ESK-NS arms showed numerically larger MADRS score reductions at week-1 and endpoint, and a significantly larger response rate compared with AAP arms. Prospective studies involving direct comparisons are warranted to compare the relative efficacy between these treatment regimens.

Keyphrases

major depressive disorder
randomized controlled trial
dengue virus
combination therapy
zika virus
placebo controlled
study protocol