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Dose-reduced first cycle of chemotherapy for prevention of life-threatening acute complications in nonseminomatous germ cell tumor patients with ultra high tumor markers and/or poor performance status.

Alexey A TryakinMikhail FedyaninAnatoly BulanovShalva KashiaIldar KurmukovVsevolod MatveevIgor FainsteinOlga GordeevaTatjana ZakharovaSergei Tjulandin
Published in: Journal of cancer research and clinical oncology (2018)
Dose reduction of the first EP cycle by 40-60% in the subgroup of poor risk patients with ultra high tumor marker levels and/or ECOG performance status 3-4 is associated with significantly lowered acute complication rates but not with overall survival.
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