Autologous red blood cell transfusion does not result in a more profound increase in pulmonary capillary wedge pressure compared to saline in critically ill patients: A randomized crossover trial.
Joachim J BosboomRobert B KlandermanLotte E TerwindtEsther B BulleMarije WijnbergeSusanne EberlAntoine H DriessenToon A WinkelmanBart F GeertsDenise P VeeloMarkus W HollmannAlexander P J VlaarPublished in: Vox sanguinis (2022)
Transfusion of autologous RBCs did not result in a more profound increase in PCWP compared to saline. RBC transfusion resulted in a decrease of EVLWI and PVPI compared to saline. Our data suggest that transfusing autologous RBCs may lead to less pulmonary oedema compared to saline. Future studies with allogeneic RBCs are needed to investigate other factors that may mediate the increase of PCWP, resulting in TACO.