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Catalytic Methylene Insertion between Amines and Terminal Alkynes via C-N Bond Cleavage of N , N -Dimethylacetamide: A Unique Route to Propargylic Amines.

Ajijur RahamanRupali Dasharath ShindeSukalyan Bhadra
Published in: The Journal of organic chemistry (2023)
A copper-based system allows for the methylene insertion between an amine and a milder nucleophile, including a terminal alkyne counterpart, via C-N bond cleavage of N , N -dimethylacetamide. The method gives an expedient access to propargylic amines in good to excellent yields. A wide-ranging substrate scope and late-stage functionalization of complex molecules make the protocol practically valuable.
Keyphrases
  • dna binding
  • randomized controlled trial
  • transition metal
  • amino acid
  • electron transfer