Anti-contactin-1 Antibodies Affect Surface Expression and Sodium Currents in Dorsal Root Ganglia.

Julia GrünerHelena StengelChristian WernerLuise AppeltshauserClaudia SommerCarmen VillmannKathrin Doppler

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

Our results demonstrate a direct effect of anti-contactin-1 autoantibodies on the surface expression of contactin-1 and sodium currents in dorsal root ganglion neurons. This may be the pathophysiologic correlate of sensory ataxia reported in these patients.

Keyphrases

spinal cord
neuropathic pain
poor prognosis
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
systemic lupus erythematosus
binding protein
spinal cord injury
optic nerve