Brain-derived neurotrophic factor predominantly regulates the expression of synapse-related genes in the striatum: Insights from in vitro transcriptomics.

Hisatsugu KoshimizuHidetada MatsuokaYoshihiro NakajimaAnna KawaiJunichiro OnoKen-Ichi OhtaTakanori MikiMasataka SunagawaNaoki Adachi Shingo Suzuki

Published in: Neuropsychopharmacology reports (2021)

The present study indicates that BDNF predominantly regulates the expression of synaptic-function-related genes and that BDNF promotes synaptogenesis in various subtypes of neurons in the developing striatum. Apold1 may represent a unique target gene of BDNF in the striatum.

Keyphrases

poor prognosis
prefrontal cortex
stress induced
binding protein
spinal cord
genome wide
single cell
copy number
dna methylation
gene expression