Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and female mice?
Kimberly F YoungRebeca GardnerVictoria SarianaSusan A WhitmanMitchell J BartlettTorsten FalkHelena W MorrisonPublished in: Journal of neuroinflammation (2021)
Our findings suggest that TMEM119 is not a stable microglia marker in male and female mice in the context of ischemic stroke. Until TMEM119 function in the brain is elucidated, its use to distinguish between cell populations following brain injury with cell infiltration is cautioned.
Keyphrases
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- single cell
- cell therapy
- inflammatory response
- atrial fibrillation
- high fat diet induced
- poor prognosis
- neuropathic pain
- stem cells
- acute myocardial infarction
- type diabetes
- resting state
- white matter
- coronary artery disease
- binding protein
- spinal cord
- bone marrow
- spinal cord injury
- left ventricular
- genetic diversity