The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination.

Lena MühlenbruchTsima Abou-KorsMarissa L DubbelaarLeon BichmannOliver KohlbacherMartin BensJaya ThomasJasmin EzićJohann M KrausHans A KestlerAdrian von WitzlebenJoannis MytilineosDaniel FürstDaphne EngelhardtJohannes DoescherJens GrevePatrick J SchulerMarie-Nicole TheodorakiCornelia BrunnerThomas K HoffmannHans-Georg RammenseeJuliane S WalzSimon Laban

Published in: British journal of cancer (2023)

Tumour-associated peptides are HLA-presented on the cell surfaces of OPSCCs. The established warehouse of OPSCC-associated peptides can be used for downstream immunogenicity testing and peptide-based immunotherapy in (semi)personalised strategies.

Keyphrases

squamous cell
amino acid
single cell
cell therapy
high grade
cystic fibrosis