Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy.
Colm J O'RourkeMassimiliano SalatiColin RaeCarpino GuidoHolly LeslieAntonio PeaMaria G PreteLuca R BonettiFrancesco AmatoRobert MontalRosie Upstill-GoddardColin NixonPaula Sanchon-SanchezPaolo KunderfrancoDaniela SiaEugenio GaudioDiletta OveriStefano CascinuDan HogdallSian PughEnric DomingoJohn N PrimroseJohn BridgewaterAndrea SpallanzaniFabio GelsominoJosep M LlovetDiego F CalvisiLuke BoulterFrancesco CaputoAna LleoNigel B JamiesonGabriele LuppiMassimo DominiciJesper B AndersenChiara BraconiPublished in: Gut (2023)
The RPLS signature could be a novel metric of chemotherapy outcome in iCCA. Further development and validation of this transcriptomic signature is warranted to develop precision chemotherapy strategies in these settings.