PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2.

Danielle E FrodymaThomas C TroiaChaitra RaoRobert A SvobodaJordan A BergDhananjay D ShindeVinai Chittezham ThomasRobert E LewisKurt W Fisher

Published in: Cancers (2022)

These findings suggest that transcriptional control of PCK2 is one mechanism used by PGC-1β and ERRα to promote glutamine metabolism and colorectal cancer cell survival.

Keyphrases

skeletal muscle
transcription factor
gene expression
poor prognosis
cell proliferation
heat shock
signaling pathway
free survival
long non coding rna
heat shock protein