Divergent Biological Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer.
Roland SeilerEwan A GibbNatalie Q WangHtoo Zarni OoHung-Ming LamKim E van KesselCharlotte S VoskuilenBrian WintersNicholas ErhoMandeep M TakharJames DouglasFunda Vakar-LopezSimon J CrabbBas W G van RhijnElisabeth E Fransen van de PutteEllen C ZwarthoffGeorge N ThalmannElai DavicioniJoost L BoormansMarc Dall'EraMichiel S van der HeijdenJonathan L WrightPeter C BlackPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
This study expands our knowledge on MIBC not responding to cisplatin by suggesting molecular subtypes to understand the biology of these tumors. Although these molecular subtypes imply consequences for adjuvant treatments, this ultimately needs to be tested in clinical trials.