Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome.
Jan ŠilhavýPetr MlejnekMiroslava ŠimákováHana MalinskaIrena MarkovaMartina HüttlDenisa MiklánkováLudmila KazdováMarek VrbackýAlena PecinováTomas MracekMichal PravenecPublished in: Metabolites (2023)
Recently, red beetroot has attracted attention as a health-promoting functional food. Studies have shown that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism; however, mechanisms underlying these beneficial effects of beetroot are not yet fully understood. In the current study, we analysed the effects of beetroot on parameters of glucose and lipid metabolism in two models of metabolic syndrome: (i) transgenic spontaneously hypertensive rats expressing human C-reactive protein (SHR-CRP rats), and (ii) hereditary hypertriglyceridemic (HHTg) rats. Treatment with beetroot juice for 4 weeks was, in both models, associated with amelioration of oxidative stress, reduced circulating lipids, smaller visceral fat depots, and lower ectopic fat accumulation in the liver compared to the respective untreated controls. On the other hand, beetroot treatment had no significant effects on the sensitivity of the muscle and adipose tissue to insulin action in either model. Analyses of hepatic proteome revealed significantly deregulated proteins involved in glycerophospholipid metabolism, mTOR signalling, inflammation, and cytoskeleton rearrangement.
Keyphrases
- adipose tissue
- metabolic syndrome
- oxidative stress
- insulin resistance
- blood pressure
- fatty acid
- type diabetes
- healthcare
- blood glucose
- high fat diet
- skeletal muscle
- working memory
- single cell
- cell proliferation
- cardiovascular disease
- social media
- health information
- replacement therapy
- induced apoptosis
- endoplasmic reticulum stress