Metabolic dysfunction-associated fatty liver disease directly related to liver fibrosis independent of insulin resistance, hyperlipidemia, and alcohol intake in morbidly obese patients.
Susumu InamineMasayoshi KageJun AkibaTakumi KawaguchiSachiyo YoshioMachiko KawaguchiDan NakanoTsubasa TsutsumiRyuki HashidaKouichi OshiroPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2022)
We determined that MAFLD was more directly associated with significant/advanced fibrosis than insulin resistance or hyperlipidemia, and alcohol intake was not directly associated with hepatic fibrosis. Metabolic dysfunction-associated fatty liver disease could be the most important factor for hepatic fibrosis in patients with morbid obesity.
Keyphrases
- obese patients
- insulin resistance
- liver fibrosis
- bariatric surgery
- high fat diet
- high fat diet induced
- adipose tissue
- gastric bypass
- metabolic syndrome
- roux en y gastric bypass
- weight loss
- polycystic ovary syndrome
- type diabetes
- skeletal muscle
- oxidative stress
- weight gain
- fatty acid
- glycemic control
- body mass index
- physical activity