Cumulative pulse methylprednisolone and its relation to disease activity, damage and mortality in systemic lupus erythematosus patients: A post hoc analysis of COMOSLE-EGYPT study.
Nesreen SobhyYasser EzzatSherif M GamalShada A GhoniemSarah S NasrShaimaa BadranAhmed SolimanNermeen Ahmed FouadPublished in: Clinical rheumatology (2024)
With every gram increase in the cumulative methylprednisolone, there may be increase in damage and mortality, especially in doses exceeding the range of 2.75-3.25 g. Key Points • Treatment of systemic lupus erythematosus should be with the least possible dose of steroids to decrease the risk of damage and mortality. • With every gram increase in the cumulative intravenous methylprednisolone there may be increase in damage and mortality.
Keyphrases
- systemic lupus erythematosus
- disease activity
- cardiovascular events
- high dose
- oxidative stress
- rheumatoid arthritis
- end stage renal disease
- rheumatoid arthritis patients
- gram negative
- ankylosing spondylitis
- ejection fraction
- blood pressure
- type diabetes
- coronary artery disease
- peritoneal dialysis
- prognostic factors
- combination therapy
- replacement therapy