A phase III randomized trial evaluating chemotherapy followed by pelvic reirradiation versus chemotherapy alone as preoperative treatment for locally recurrent rectal cancer - GRECCAR 15 trial protocol.
Quentin DenostEric FrisonCécile SalutRemy SittaAnne RullierDeena HarjiHelene Maillou-MartinaudEric RullierDenis SmithVeronique Vendrelynull nullPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2021)
The GRECCAR 15 trial is the first, definitive, phase III trial to investigate reirradiation in LRRC. The results of this trial will inform definitively the neoadjuvant treatment strategy in previously irradiated patients and assess whether there is any associated benefit of reirradiation in combination with induction chemotherapy in improving R0 resection rates.
Keyphrases
- phase iii
- locally advanced
- rectal cancer
- open label
- clinical trial
- phase ii
- double blind
- placebo controlled
- squamous cell carcinoma
- study protocol
- randomized controlled trial
- ejection fraction
- radiation therapy
- end stage renal disease
- newly diagnosed
- lymph node
- patients undergoing
- combination therapy
- patient reported outcomes