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Epidemiology of growth hormone deficiency in children and adolescents: a systematic review.

Chiara MameliLiliana GuadagniMassimiliano OrsoValeria CalcaterraMalgorzata Gabriela WasniewskaTommaso AversaSimona GranatoPietro BruschiniDaniela d'AngelaFederico SpandonaroBarbara PolistenaGian Vincenzo Zuccotti
Published in: Endocrine (2024)
The included studies are mostly European, so the provided estimates cannot be considered global. International multicentre studies are needed to compare epidemiological estimates of GHD among different ethnical groups. Considering the considerable cost of human recombinant GH, the only available therapy to treat GHD, understanding accurate epidemiological estimates of GHD in each country is fundamental for resource allocation.
Keyphrases
  • growth hormone
  • endothelial cells
  • case control
  • risk factors
  • study protocol
  • cross sectional
  • replacement therapy
  • smoking cessation