Engineered rare-earth nanomaterials for fluorescence imaging and therapy.
Hongru WangZheng WeiYangyang ZhaoShidong WangLili CaoFan WangKai LiuYanfei SunPublished in: RSC advances (2023)
Early diagnosis and treatment are of great significance for hindering the progression of brain disease. The limited effects of available treatments and poor prognosis are currently the most pressing problems faced by clinicians and their patients. Therefore, developing new diagnosis and treatment programs for brain diseases is urgently needed. Near-infrared (NIR)-light-responsive, lanthanide-doped upconversion nanoparticles (UCNPs) provide great advantages both in diagnosis and therapy. Hence, we synthesised nanoparticles comprised of a UCNPs core with surface functionalization. UCNPs@Au was used for NIR fluorescence imaging in the brain and inhibiting the growth of mouse glioma 261 (GL261) cells depending on photothermal properties. In addition, a UCNPs core and a mesoporous silica layer as the outer shell with a tannic acid-Al 3+ ions (TA-Al) complex as a "gatekeeper" were used for pH-triggered doxorubicin/small interfering ribonucleic acid delivery in vitro . Based on our preliminary results, we expect to develop more multifunctional nanoscale diagnostic and therapeutic agents based on UCNPs for the diagnosis and treatment of brain diseases, including Alzheimer's disease, Parkinson's disease, and brain tumours.
Keyphrases
- fluorescence imaging
- photodynamic therapy
- resting state
- poor prognosis
- white matter
- cancer therapy
- functional connectivity
- drug delivery
- long non coding rna
- cerebral ischemia
- quantum dots
- newly diagnosed
- ejection fraction
- mental health
- induced apoptosis
- public health
- drug release
- end stage renal disease
- sensitive detection
- oxidative stress
- mesenchymal stem cells
- prognostic factors
- cell proliferation
- patient reported outcomes
- bone marrow
- fluorescent probe
- peritoneal dialysis
- aqueous solution
- energy transfer