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Radiotherapy Combined With Nivolumab or Temozolomide for Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter: An International Randomized Phase 3 Trial.

Antonio OmuroAlba A BrandesAntoine F CarpentierAhmed IdbaïhDavid A ReardonTimothy CloughesyAshley SumrallJoachim BaehringMartin J Van Den BentOliver BährGiuseppe LombardiPaul MulhollandGhazaleh TabatabaiUlrik LassenJuan Manuel SepulvedaMustafa KhasrawElodie VauleonYoshihiro MuragakiAnna Maria Di GiacomoNicholas ButowskiPatrick RothXiaozhong QianAlex Z FuYanfang LiuVon PotterAlexandros-Georgios ChalamandarisKay TatsuokaMichael LimMichael Weller
Published in: Neuro-oncology (2022)
The study did not meet the primary endpoint of improved OS; TMZ+RT demonstrated a longer median OS than NIVO+RT. No new safety signals were detected with NIVO in this study. The difference between the study treatment arms is consistent with the use of TMZ+RT as standard of care for glioblastoma.
Keyphrases
  • newly diagnosed
  • gene expression
  • early stage
  • randomized controlled trial
  • dna methylation
  • radiation therapy
  • transcription factor
  • open label
  • locally advanced
  • study protocol
  • smoking cessation