Comparative Risk of Gout Flares When Initiating or Escalating Various Urate-Lowering Therapy: A Systematic Review With Network Meta-Analysis.

Dorsa MaherEmily ReeveAshley HopkinsJiun Ming TanMahsa TantiongcoNagham AilabouniRichard WoodmanLisa K StampDavid BursillSusanna ProudmanMichael D Wiese

Published in: Arthritis care & research (2024)

The RR of flares when introducing ULT varies depending on ULT drug and dosing strategies. There were limited data on ULT escalation. Flare prophylaxis with colchicine and rilonacept reduces flare incidence. More research is required on the harms and optimal duration of prophylaxis.

Keyphrases

systematic review
risk factors
meta analyses
electronic health record
uric acid
big data
case control
stem cells
metabolic syndrome
emergency department
randomized controlled trial
data analysis
network analysis
deep learning
replacement therapy