Is There a Role for FAPI PET in Urological Cancers?
Naima OrtolanLuca UrsoIlaria ZamberlanLuca FilippiNicolò Maria BuffiCorrado CittantiLicia UccelliMirco BartolomeiLaura EvangelistaPublished in: Molecular diagnosis & therapy (2024)
This work aims to investigate the utility of positron emission tomography/computed tomography (PET/CT) with fibroblast activation protein inhibitors (FAPI) in urological neoplasms, including prostate cancer, urothelial carcinoma, and renal cell carcinoma. Although the available data are very preliminary, FAPI PET showed potential for detecting primary prostate cancer with low prostate-specific membrane antigen expression, while prostate-specific membrane antigen PET/CT outperformed FAPI PET/CT in detecting biochemical recurrence. In urothelial carcinoma, FAPI PET/CT demonstrated increased detection rates compared with deoxy-2-[18F]fluoro-D-glucose PET/CT, in particular in small lymph node metastases, whose identification is still an unmet clinical need. Limited data are available for renal cell carcinoma. In conclusion, FAPI PET emerges as a promising imaging modality for urological neoplasms, in particular bladder cancer. Further research is warranted to establish its role in guiding therapeutic decisions and as a potential novel theranostic agent.
Keyphrases
- pet ct
- positron emission tomography
- prostate cancer
- renal cell carcinoma
- computed tomography
- radical prostatectomy
- lymph node
- pet imaging
- electronic health record
- high resolution
- poor prognosis
- big data
- benign prostatic hyperplasia
- photodynamic therapy
- blood pressure
- adipose tissue
- binding protein
- urinary tract
- magnetic resonance imaging
- neoadjuvant chemotherapy
- blood glucose
- squamous cell carcinoma
- long non coding rna
- risk assessment
- sentinel lymph node
- locally advanced
- contrast enhanced