Acute Ethanol Produces Ataxia and Induces Fmr1 Expression via Histone Modifications in the Rat Cerebellum.

Russell S DulmanJames AutaTara TeppenSubhash C Pandey

Published in: Alcoholism, clinical and experimental research (2019)

Overall, EtOH regulates cerebellar Fmr1 expression most likely via HAT-mediated increase in histone acetylation. We propose that FMRP regulation of glutamatergic transcripts plays an important role in disrupting the excitatory-inhibitory balance in the cerebellum underlying EtOH-induced ataxia.

Keyphrases

poor prognosis
dna methylation
early onset
liver failure
binding protein
long non coding rna
diabetic rats
intensive care unit
aortic dissection
histone deacetylase