Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes.

Ben M AlbertsJames S BarberSandra M Sacre Kevin A Davies Pietro Ghezzi Lisa M Mullen

Published in: The Journal of rheumatology (2019)

Despite reports indicating that soluble UA can prime and activate the NLRP3 inflammasome in human peripheral blood mononuclear cells, precipitation of soluble UA into MSU crystals is essential for in vitro NLRP3 signaling in primary human monocytes.

Keyphrases

nlrp inflammasome
endothelial cells
uric acid
induced pluripotent stem cells
metabolic syndrome
pluripotent stem cells
peripheral blood
immune response