GNRHR-related central hypogonadism with spontaneous recovery - case report.

Darja Šmigoc SchweigerMaja Davidović PovšeKatarina Trebušak PodkrajšekTadej BattelinoMagdalena Avbelj Stefanija

Published in: Italian journal of pediatrics (2022)

Genetic diagnostics can help discriminate congenital hypogonadotropic hypogonadism, deserving therapeutic intervention, from the self-limited constitutional delay of growth and puberty (CDGP). Patients with GNRHR associated hypogonadism can experience spontaneous recovery of the hypothalamic-pituitary-gonadal axis. Spontaneous testis enlargement in patients with central hypogonadism not taking gonadotropins or pulsatile GnRH therapy can indicate recovery of hypogonadism.

Keyphrases

replacement therapy
case report
randomized controlled trial
smoking cessation
stem cells
genome wide
gene expression
dna methylation