Optimized Polyethylene Glycolylated Polymer-Lipid Hybrid Nanoparticles as a Potential Breast Cancer Treatment.

Salam MassadehMustafa E OmerAsmaa AlterawiRizwan AliFayez H AlanaziFares AlmutairiWejdan AlmotairiFaris F AlobaidiKhulud AlhelalMansour S AlmutairiAbdulaziz AlmalikAiman A ObaidatManal AlaameryAlaa Eldeen B Yassin

Published in: Pharmaceutics (2020)

PEGylated polymeric nanoparticles presented a stable encapsulated system with which to incorporate an anticancer drug (ANS) with a high percentage of entrapment efficiency (around 80%), good size uniformity, and induction of apoptosis in MCF-7 cells.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
pi k akt
oxidative stress
drug delivery
breast cancer cells
signaling pathway
cancer therapy
fatty acid
emergency department
risk assessment
climate change
electronic health record
recombinant human