Magnetic Resonance Imaging Measures to Track Atrophy Progression in Progressive Supranuclear Palsy in Clinical Trials.
Andrea QuattroneNicolai FranzmeierHans-Jürgen HuppertzMartin KlietzSebastian N RoemerAdam L BoxerJohannes LevinGünter U Höglingernull nullPublished in: Movement disorders : official journal of the Movement Disorder Society (2024)
This evidence may inform the selection of imaging endpoints to assess the treatment efficacy in reducing brain atrophy rate in PSP clinical trials, with automated atlas-based volumetry requiring smaller sample size than staging systems and planimetry to observe significant treatment effects. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- clinical trial
- magnetic resonance imaging
- computed tomography
- multiple sclerosis
- machine learning
- lymph node
- high resolution
- randomized controlled trial
- combination therapy
- deep learning
- white matter
- high throughput
- pet ct
- subarachnoid hemorrhage
- blood brain barrier
- phase ii
- open label
- phase iii
- functional connectivity
- diffusion weighted imaging