Phase I trial of dose escalation for preoperative stereotactic radiosurgery for patients with large brain metastases.
Erin S MurphyKailin YangJohn H SuhJennifer S YuGlen StevensLilyana AngelovMichael A VogelbaumGene H BarnettManmeet S AhluwaliaGennady NeymanAlireza M MohammadiSamuel T ChaoPublished in: Neuro-oncology (2024)
Preoperative SRS with dose escalation followed by surgical resection for brain metastases greater than 2 cm in size demonstrates acceptable acute toxicity. The phase II portion of the trial will be conducted at the maximum tolerated SRS doses.