Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the "Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions".
Maria Aparecida Shikanai YasudaMauro Felippe Felix MedianoChristina Terra Gallafrio NovaesAndréa Silvestre de SousaAna Marli Christovam SartoriRodrigo de Carvalho SantanaDalmo CorreiaCleudson Nery de CastroMarilia Maria Dos Santos SeveroAlejandro Marcel Hasslocher-MorenoMarisa Liliana FernandezFernando SalvadorMaria Jesús PinazoValdes Roberto BolellaPedro Carvalho FurtadoMarcelo CortiAna Yecê Neves PintoAlberto FicaIsrael Molina RomeroJoaquim GascónPedro Albajar ViñasJuan José Cortez-EscalanteAlberto Novaes Ramos JuniorEros Antonio de AlmeidaPublished in: PLoS neglected tropical diseases (2021)
This study showed major features on T. cruzi-HIV co-infection and highlighted the prognostic role of CD4+ cells for reactivation and mortality. Since lethality was high in meningoencephalitis and all untreated patients died shortly after the diagnosis, early diagnosis, immediate antiparasitic treatment, patient follow-up and epidemiological surveillance are essentials in T. cruzi/HIV co-infection and CDR managements.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- healthcare
- men who have sex with men
- end stage renal disease
- public health
- cardiovascular events
- trypanosoma cruzi
- newly diagnosed
- induced apoptosis
- south africa
- type diabetes
- clinical trial
- cell death
- signaling pathway
- peritoneal dialysis
- cross sectional
- cell cycle arrest
- prognostic factors
- big data
- social media
- patient reported outcomes
- cell proliferation
- network analysis