Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.
Molly WentBen KinnersleyAmit SudDavid C JohnsonNiels WeinholdAsta FörstiMark van DuinGiulia OrlandoJonathan S MitchellRowan KuiperBrian A WalkerWalter M GregoryPer HoffmannGraham H JacksonMarkus M NöthenMiguel Inacio da Silva FilhoHauke ThomsenAnnemiek BroylFaith E DaviesUnnur ThorsteinsdottirMarkus HanssonMartin KaiserPieter SonneveldHartmut GoldschmidtKari StefanssonKari HemminkiBjörn NilssonGareth J MorganRichard S HoulstonPublished in: Human genomics (2019)
Our findings highlight the value of leveraging expression data from multiple tissues to identify candidate genes responsible for GWAS associations which provide insight into MM tumorigenesis. Among the genes identified, a number have plausible roles in MM biology, notably APOBEC3C, APOBEC3H, APOBEC3D, APOBEC3F, APOBEC3G, or have been previously implicated in other malignancies. The genes identified in this TWAS can be explored for follow-up and validation to further understand their role in MM biology.