Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery.
Tina JorsalMarie M ChristensenBrynjulf MortensenEva B NygaardChen ZhangKristoffer RigboltErik WandallEbbe LangholzSteffen FriisDorte WormAndrea FloydFrederik HelgstrandRené K StøvingAlin R AldriesClaus B JuhlTorben ØstergaardThomas RydborgJulie L FormanFrederik SørensenTorsten SchmidtMechthilde FalkenhahnPetra B MusholtStefan TheisPhilip J LarsenJens F RehfeldNiels VrangJacob JelsingTina VilsbøllFilip K KnopPublished in: Obesity (Silver Spring, Md.) (2021)
RYGB affects the transcription of a wide range of genes, indicating that the observed beneficial metabolic effects of RYGB may rely on a changed expression of several genes in the gut. RYGB-induced changes in the expression of genes encoding signaling peptides and G protein-coupled receptors may disclose new gut-derived treatment targets against obesity and diabetes.
Keyphrases
- roux en y gastric bypass
- weight loss
- gastric bypass
- gene expression
- obese patients
- genome wide
- poor prognosis
- bariatric surgery
- type diabetes
- genome wide identification
- bioinformatics analysis
- cardiovascular disease
- glycemic control
- minimally invasive
- dna methylation
- metabolic syndrome
- insulin resistance
- binding protein
- weight gain
- body mass index
- coronary artery disease
- physical activity
- adipose tissue
- ulcerative colitis
- combination therapy
- percutaneous coronary intervention