Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium.
Yuki NarukawaNaoyuki SugiyamaJiro MiuraRentaro YamashitaShotaro TominagaYoshihiro IzumiTakeshi BambaYasushi IshihamaYoichiro KashiwagiShinya MurakamiPublished in: Journal of periodontal research (2023)
High glucose-induced impairment of intercellular adhesion molecule expression in gingival epithelial cells was related to the intercellular permeability of gingival cells, representing a possible link to hyperglycemia-related AGE signaling, oxidative stress, and ERK1/2 activation.
Keyphrases
- high glucose
- cell adhesion
- endothelial cells
- diabetic rats
- oxidative stress
- poor prognosis
- induced apoptosis
- cell cycle arrest
- signaling pathway
- dna damage
- drug induced
- pi k akt
- binding protein
- cell proliferation
- long non coding rna
- ischemia reperfusion injury
- pseudomonas aeruginosa
- cell death
- cystic fibrosis
- stress induced
- candida albicans