Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose tissues in the mouse.

Marissa McGilvreyBethany FortierBenjamin TeroDiana CookeEmily CooperJeffrey WalkerRobert KozaGene P Ables Lucy Liaw

Published in: Obesity (Silver Spring, Md.) (2022)

Lipid in mouse PVAT peaked at 1 year of age, consistent with peak body mass. MetR reduced body weight, normalized metabolic parameters, and decreased lipid in PVAT in all age cohorts. Mice fed a MetR diet from early maturity to 1 year of age displayed an increased thermogenic adipocyte phenotype in iWAT, PVAT, and BAT, all tissues with thermogenic capacity.

Keyphrases

body weight
fatty acid
adipose tissue
gene expression
insulin resistance
physical activity
weight loss
metabolic syndrome
skeletal muscle
high fat diet induced
amino acid